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March 22, 2010
In Today's Issue
- Overweight? Shocking Proof that it may not be your fault
- Very Obese Have Missing Genes
- Ex-soldier Fitness Trainer Reveals Military's Top Secret...
Overweight? Shocking Proof that it may not be your fault
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Very Obese Have Missing Genes
Dear Reader,
Theories that associate DNA to weight have just gotten a major boost due to the discovery by European researchers of a genetic variation that almost guarantees a person will be obese.
The variation in question appears in 7 out of every 1,000 severely obese people, and may also be linked to mental retardation and learning disabilities. The investigation appears in the February 4. 2010 issue of the British journal Nature.
The work, conducted by a team of European scientists, began by examining the genes of teens and adults who had learning problems and developmental delays.
Of these, 31 were missing the genes in question and all of these subjects were obese, with BMIs over 30.0. This led the researchers to look at the genomes of 16,053 healthy people who were either of normal weight or obese, of these, 19 people had the same set of missing genes, and all were severely obese. The genetic variation was not found in any of the normal weight subjects.
Interestingly, the obese subjects reported being average weight toddlers, but steadily gaining weight during childhood, and getting to the severely obese stage as an adult.
"Obesity is definitively a genetic trait, and it is very likely that additional small chromosomal abnormalities exist that may dramatically increase the risk of obesity and may also be linked to brain developmental problems," explains study co-author Dr. Philippe Froguel, the head of genomic medicine at Imperial College London.
While other studies have looked at different genetic variations that might contribute to obesity, this is the first to clearly show that a relatively rare genetic variation is also part of the obesity puzzle.
Obesity in otherwise healthy adults may be caused by a variation where a section of that person's DNA is missing. But just what the missing genes do in the body, and how the lack of them brings on obesity, remains unknown.
Some basic genetics might help here. We all inherit two copies of our DNA, one from our mother, the other from our father. The trouble starts when a child is missing a copy of one, or several, of these genes, and this can have a profound impact on the body. Experts believe these defects may make the bodily reaction to our modern unhealthy environment (junk food, no exercise, lack of sleep) far different from another person's.
Continues below...
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Very Obese Have Missing Genes Continued...
"
The mechanism by which this genetic defect unveils itself may give us insight into how other conditions lead to obesity. There may be an enzyme or a protein that is involved in the development of obesity," explains Dr. Stuart Weiss, an assistant clinical professor at NYU Langone Medical Center, who is familiar with the study and its findings.
This work might lead to medications and therapies that could turn something in the body on (or off) and effect body weight. It may also allow for ways to identify those at risk through genetic testing and offer support and medical intervention as needed.
Weiss points out that not all obese people can slim down just by eating less and exercising more. This may be especially true if the body is set up to extract calories or burn energy less efficiently, encouraging weight gain.
The good news for anyone struggling with obesity is that we may be getting closer to the day when medicine can offer real help, real hope, to those wanting to lose the weight.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://news.yahoo.com/s/hsn/20100204/hl_hsn/
veryobesepeoplemaybemissinggenes
The journal Nature, February 4, 2010:
http://www.nature.com/nature/journal/v463/n7281/full/
nature08727.html
National Institute of Health info on obesity:
http://health.nih.gov/topic/Obesity
Dr. Philippe Froguel, the head of genomic medicine at Imperial College London:
http://www1.imperial.ac.uk/medicine/people/p.froguel/
Dr. Stuart Weiss, an assistant clinical professor at NYU Langone Medical Center:
http://www.med.nyu.edu/clinicians/weisss02.html
Imperial College new release on study:
http://www.eurekalert.org/pub_releases/2010-02/icl-smo020210.php
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