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April 13, 2010
In Today's Issue
- The Biggest Loser's Twins Proven Weight Loss Techniques
- New Way To Reduce High Blood Pressure
- Overweight? Shocking Proof that it may not be your fault
The Biggest Loser's Twins Proven Weight Loss Techniques
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New Way To Reduce High Blood Pressure
Dear Reader,
Good news for high blood pressure patients. The results of a recent manufacturer sponsored clinical trial published in an online edition of The Lancet suggest that combining a new blood pressure lowering drug with an existing one offers some pretty impressive benefits.
The drug, Novartis's AHU377 is a member of a new class of medications known as vasopeptidase inhibitors - you may have heard of an earlier drug of equal promise, Bristol-Myers Squibb's omipatrilat, however that was found to have a dangerous side effect - swelling of parts of the body, including the throat.
AHU377 thankfully doesn't display this side effect, but it's not a very powerful medication alone. By combining this new medication with an existing drug - Diovan also from Novaritis - the blood pressure lowering effects were far better, significantly boosting the effects of Diovan.
The combination of the two types of drugs creates a new molecule: an ARNI or "dual-acting angiotensin II-receptor and neprilysin inhibitor," explains Luis Miguel Ruilope, MD, of Hospital 12 October in Madrid, Spain.
Ruilope and his colleagues tested the new combination (known as LCZ696) on 1,328 adults aged 18 to 75 living in eighteen different nations.
The participants had mild to moderate high blood pressure, on average 156/100 (normal is 120/80, or less) and were randomly assigned to one of eight treatment groups for the eight week long study.
At every dose tested LCZ696 enhanced the blood pressure lowering effect of Diovan.
The dose that will be used for further clinical trials is 200 milligrams. If these studies bring similar results, the systolic blood pressure (top number) of the subjects will drop by as much as 11 points. Diastolic blood pressure (bottom number) will drop by as much as 6.14 points.
Diovan alone has been shown to bring systolic blood pressure down by 5.69 points; diastolic pressure down by 3.17 points - so you can see quite a difference in the readings when the medications are combined. Best of all, those taking LCZ696 had no more side effects than those taking the placebo.
"The new drug LCZ696... has great potential," write Bernard Waeber and François Feihl of the University of Lausanne in Switzerland, in the same iss- of The Lancet.
Experts believe that LCZ696 works in two ways. Part of the job it does is to block a protein (angiotensin-2) from binding to a receptor protein on cells, so cells don't constrict and bring up blood pressure. The drug also keeps a troublesome compound in check, allowing the substance called atrial natriuretic peptide (ANP for short) to be produced by the heart and circulate to induce the kidneys to flush salt and water - a completely natural, already built-in blood pressure controller, without diuretic side effects.
Medications aren't the only way to bring those blood pressure numbers down. There
are other things, all within your control and entirely natural, that you can
do to help yourself:
- Losing weight cuts your systolic blood pressure by 5 to 20 points for every 22 pounds you lose.
Continues below...
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New Way To Reduce High Blood Pressure Continued...
- Regular exercise cuts systolic pressure by 4-9 points.
- The DASH diet (low in fat, high in veggies and fruits) cuts systolic blood
pressure by 8 to 14 points.
- Limiting alcohol to no more than two drinks a day (men) and one drink a day
(women) reduces systolic blood pressure by 2-4 points.
Almost 75 million American adults have high blood pressure, and this condition
continues to be a major health threat all over the world.
Anyone can have it,
especially if you have a family history of the disease, if you smoke or are obese
or diabetic.
The good news is that most often high blood pressure can be controlled
(or at least improved) with both medication and lifestyle changes.
The next steps are for researchers to test LCZ696 in those with heart failure
(with or without hypertension), as the relaxation of vessels could be a clear
benefit to these patients.
If you're interested, there are clinical trials recruiting
right now to test LCZ696 against other medications for chronic heart failure.
There will also be trials on subjects who have serious high blood pressure as
well as anyone taking lots of medications.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.webmd.com/hypertension-high-blood-pressure/news/20100316/new-combo-drug-may-cut-blood-pressure?src=RSS_PUBLIC
Full text of study, March 16, 2010 iss- of The Lancet:
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61966-8/fulltext
Article on blood pressure reduction with LCZ696 In The Lancet, early online publication:
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60363-7/fulltext
American Heart Association info on high blood pressure:
http://www.americanheart.org/presenter.jhtml?identifier=2114
WebMD info on high blood pressure:
http://www.webmd.com/hypertension-high-blood-pressure/guide/blood-pressure-causes
ScienceNews story on experimental blood pressure drug:
http://www.sciencenews.org/view/generic/id/57358/title/Experimental_
blood_pressure_drug_takes_natural_approach
Are you at a healthy weight:
http://www.webmd.com/diet/tc/healthy-weight-what-is-a-healthy-weight
WebMD health and fitness info:
http://www.webmd.com/fitness-exercise/guide/default.htm
The DASH diet:
http://www.webmd.com/hypertension-high-blood-pressure/dash-diet
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