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May 11, 2010
In Today's Issue
- 1 Quick Technique To Burn More Fat
- Are Statins Right For Healthy People? Maybe
- Overweight? Shocking Proof that it may not be your fault
1 Quick Technique To Burn More Fat
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Are Statins Right For Healthy People? Maybe
Dear Reader,
If you're healthy, without high cholesterol levels, should you be taking a cholesterol-lowering drug? For some, the controversial and still debatable answer is "yes". The reason is a compelling one...
Half of all heart attacks (and strokes too) happen in those who appear perfectly healthy, with LDL (bad) cholesterol numbers that are below the current levels of concern to doctors. It's this that has experts wondering if these patients could benefit from a statin drug.
To find the answer, the JUPITER clinical trial, funded by AstraZeneca, enrolled 17,802 men (over the age of 50) and women (over 60) with high CRP levels, but who also had LDL cholesterol under 130 mg/dL. The average LDL level of the subjects was 108 mg/dL.
An independent review panel stopped the trial when it became obvious that the subjects getting a placebo were having more heart attacks, strokes, angina and death from heart disease than those who were taking 20 milligrams of Crestor each day.
The risk wasn't a major one... there were 251 heart disease events in the 8,801 placebo patients, 142 events in the subjects taking Crestor. The 44% relative reduction is still twice as great as what experts have seen in most clinical trails of statins that used subjects with high LDL cholesterol levels.
In February 2010, the FDA approved using statin Crestor (from maker AstraZeneca) for preventing first time heart disease in those with normal LDL cholesterol.
To be given the drug, a patient must be over 50 if you're a man; over 60 if you're a woman, must also have high blood levels of C-reactive protein (CRP) at or over 2 mg/L (considered very high) a clue to inflammation in the body, and at least one other risk factor for heart disease such as high blood pressure, low good cholesterol, smoking or family history of early heart disease.
Statins are a class of drugs that block an enzyme in the liver that is responsible for making cholesterol, and this keeps blood levels lower.
Continues below...
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Are Statins Right For Healthy People? Maybe Continued...
Today 80 million people are using this class of medications. Beyond Crestor,
the drugs on the market include Lescol, Lipitor, Mevacor, Pravachol and Zocor.
You should keep in mind that despite what you've heard in ads for these products,
cholesterol does have its uses - its critical to the functioning of every cell
in the body, though it also contributes to the development of atherosclerosis.
The coronary arteries are especially vulnerable.
If you have concerns about your cholesterol levels or heart disease risk, it's
best to talk with your doctor about this research.
Remember that different patients have their own unique constellation of risk
factors for heart problems, and there are also a variety of reasons why they
should (or should not) take these type of medications. The choice is not an easy
one.
Treatment with statins usually continues for life, and is not cheap. The drug
costs $3.45 a day. You should also know that all drugs, including these, have
some risks and side effects, though most troubling is a link between statin use
and increased risk of diabetes. In the JUPITER trial, more of those taking Crestor
developed diabetes than those who took the placebo, though it did appear to happen
more often in those over 60, and is a risk that comes with all statin drugs.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=115050
MedicineNet info on heart disease: http://www.medicinenet.com/heart_disease/article.htm
MedicineNet info on statin drugs: http://www.medicinenet.com/statins/article.htm
ClinicalTrails.gov info on JUPITER clinical trial: http://clinicaltrials.gov/ct2/show/NCT00239681
FDA approval of new indication for Crestor: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements
/ucm200128.htm
Q & A for healthcare professionals: Crestor and the JUPITER trial: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafety
InformationforPatientsandProviders/ucm199891.htm
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