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July 16, 2010
In Today's Issue
- 1 Quick Technique To Burn More Fat
- New 'Natural' Chemo Drug Increases Survival In Breast Cancer...
- WARNING: The truth about Moles, Warts and Skintags...
1 Quick Technique To Burn More Fat
Here's Your Free Presentation To Discover: The 1 sneaky technique to trick our bodies to burn more fat... How a unique, simple and quick NEW way of moving eliminates fat - Hint: it's the exact opposite of boring cardio, but with no cardio at all... How a tasty little dish eaten late at night actually boosted the most powerful fat loss hormone in our bodies while you sleep... Click through here now to discover how to burn more fat quicker today...*Disclosure: compensated affiliate*
New 'Natural' Chemo Drug Increases Survival In Breast Cancer...
Dear Reader,
A drug that comes from sea sponges has been found to extend the life of breast cancer patients whose cancer recurred even after five rounds of chemo, by an average of 10 weeks. That might not sound like much, but in the world of the seriously ill facing death, those extra days and weeks are beyond price. It's something doctors can offer patients whose outlook is poor so that they can be a part of a special event.
Eribulin is a new compound discovered and developed by Eisai. It is naturally derived compound that came from a marine sponge and is used as a chemo drug that works against the scaffolding that protects cancer cells, interfering with cell division and causing the cells to die off instead. This approach is used by older chemotherapy medications (taxanes) that work on a different part of the scaffolding.
The study involved 762 breast cancer patients whose tumors had spread despite chemotherapy, two thirds of them took the experimental drug eribulin given in a two to five minute IV infusion on day 1 and day 8 of a 21 day cycle.
The rest got whatever treatment (chemo, hormonal or biological therapy) their oncologist thought best. Sometimes this was another chemotherapy agent, in other cases only supportive care for pain and fatigue.
Eribulin takers lived an average of about 13 months, and were 19% less likely to die. Their cancer stayed in control a bit longer - 3.7 months vs. 2.2 months.
Tumors shrank by 30% (or more) in 12.2% of women taking the drug, vs. 4.7% of women in the other group. Christopher Twelves, MD, PhD of England's St. James Hospital presented the results of the late stage phase III trial at the annual meeting of the American Society of Clinical Oncology. He also consults for the company who makes the drug and funded the research.
After skin cancer, cancer of the breast is the most common cancer in U.S. women though rates have fallen in recent years.
Women fear it, and we're encouraged to do monthly self exams and undergo annual screenings in an effort to detect such cancers early.
Despite all this, during 2010 an estimated 207,000 women will be diagnosed with breast cancer, and though rarer, nearly 2,000 men. Earlier diagnosis and better treatments are giving these patients the best chance yet of long-term survival.
Still, almost a third will develop metastatic disease that can't be cured with the treatments we have today. For these patients eribulin is another much-needed option.
The downside?
Continues below...
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WARNING: The truth about Moles, Warts and Skintags...
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Click through now to discover safe, painless and effective ways to permanently remove moles, warts or skin tags in three days...
*Disclosure: compensated affiliate*
New 'Natural' Chemo Drug Increases Survival In Breast Cancer... Continued...
About 4% of those taking eribulin did develop a potentially life threatening
condition known as febrile neutropenia that brings fever, infection and low white
blood cell count. This was about three times the rate of women getting standard
treatment. Overall, the rate of serious side effects was the same in both groups,
affecting one in four of the women.
The more common side effects of eribulin are fatigue, weakness, low white blood
cell counts, hair loss and nausea - familiar to most chemotherapy patients today.
The good news, according to Twelves is that only 4.8% of women had to stop the
treatment due to side effects.
If you're interested in eribulin, you need to talk with your oncologist. This
may be one of the last chemotherapy agents approved for breast cancer as most
of the newer drugs (Herceptin and Tykerb) work differently, targeting specific
molecular defects that fuel some types of tumors.
Eribulin has gotten a priority review for approval by the FDA, putting the medication
on the fast track to approval within just 6 months compared to the standard ten
months.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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*Disclosure: compensated affiliate*
Sources:
http://www.webmd.com/breast-cancer/news/20100607/sea-sponge-drug-may-fight-breast-cancer?src=RSS_PUBLIC
Eisai Inc press release on study:
http://www.medicalnewstoday.com/articles/169384.php
Info on Eribulin:
http://en.wikipedia.org/wiki/Eribulin
WebMD info on breast cancer:
http://www.webmd.com/breast-cancer/
National Cancer Institute info on breast cancer:
http://www.cancer.gov/cancertopics/types/breast
WebMD info on Herceptin IV:
http://www.webmd.com/drugs/drug-16621-herceptin+iv.aspx
WebMD info on Tykerb Oral:
http://www.webmd.com/drugs/drug-147813-tykerb+oral.aspx
Story on FDA granting priority review to eribulin:
http://www.news-medical.net/news/20100602/FDA-grants-priority-review-status-to-Eisais-eribulin-NDA.aspx?utm_source=twitterfeed&utm_medium=twitter&utm_
campaign=DTN+Pharma+News:
American Society of Clinical Oncology annual meeting:
http://chicago2010.asco.org/
Christopher Twelves, MD, PhD, St. James Hospital, England:
http://www.zoominfo.com/Search/PersonDetail.aspx?
PersonID=58753418
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