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July 22, 2010
In Today's Issue
- Overweight? Shocking Proof that it may not be your fault
- How Red Wine Might Help Your Weight and Heart...
- Professional Trainer (CPT) Reveals Truth About Quick Fat Loss...
Overweight? Shocking Proof that it may not be your fault
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How Red Wine Might Help Your Weight and Heart...
Dear Reader,
We've all heard that drinking red wine is good for your heart, now two studies have given experts important clues on just how these richly colored wines deliver their heart healthy benefits along with the great taste. The two studies along with an accompanying editorial appear in the July 2010 issue of the Journal of Clinical Nutrition.
In the first study, researchers out of the University of Ulm in Germany examined the biological behavior of resveratrol in human fat cells. This is the substance, found in the skin of red grapes, that's been shown to be a potential protection against heart disease, cancer, diabetes and neurodegenerative diseases such as Alzheimer's disease. The hypothesis of the researchers was that this substance might cut obesity by preventing young fat cells from maturing while also activating sirtuin 1, a protein that protects our heart from inflammation.
In the lab, resveratrol was found to influence fat cells' form and function. It was not only able to stop the young cells from maturing; this kept them from differentiating and in turn affected their ability to function. While earlier work has used animals to look at the effects of resveratrol, this is the first research to be done on actual human fat cells.
The team also noticed that resveratrol did other things - stimulating glucose uptake into the fat cells and blocking molecules from changing into fat. It also helped the Sirt 1 protein and the secretion of adipokines, the fat cells that actually do the cell-to-cell talking. It may be that resveratrol prevents obesity to some extent, maybe by acting on that all-important cell signaling, while also supporting other metabolic effects that lead to a healthy heart.
Obesity, a major, well known risk factor for heart disease, could be treated with this substance according to researchers who point out that the World Health Organization estimates there are 1.6 billion people over the age of 15 who are overweight (BMI of 25.0-29.9), and at least 400 million people who are obese (BMI over 30.0). These numbers are expected to grow in the years to come.
The second of the two studies comes from the Israel Institute of Technology and finds that red wine enhanced the health of blood vessel cells.
The work involved 15 healthy adults (mean age 29) who consumed 250 mL (8.5 ounces) of red wine each day for three weeks in a row. The subjects gave blood samples at the beginning and end of the study period.
The team found that drinking red wine significantly enhanced vascular endothelial function - in other words, it improved the health of blood vessels, which in turn improves blood flow and the health of the heart itself.
Continues below...
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How Red Wine Might Help Your Weight and Heart... Continued...
Drinking the red wine each day also seemed to reduce apoptosis, or cell death.
In populations where red wine is a mainstay, the prevalence of cardiovascular
disease is low according to the researchers.
Drinking moderate amounts does provide some protection to your heart. It may
be that red wine increases nitric oxide availability and triggers a cellular
communication process that's needed for blood vessels to work properly. The endothelial
cells in blood vessels rely on nitric oxide to tell the vessel tissue to relax,
and this helps blood flow. The red wine appears to facilitate the communication
that gets this process going.
In an editorial published along with the two studies, experts from the National
Institute on Aging in Bethesda, Maryland call for clinical trials to measure
the effect of red wine and assess the compounds ability to reverse existing cardiovascular
disease. The new insights are welcome, though questions linger regarding red
wine's biological properties and mechanism of action.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=117428
Fischer-Posovszky, P. American Journal of Clinical Nutrition, July 2010:
http://www.ajcn.org/cgi/content/abstract/92/1/5
World Health Organization info on obesity and overweight:
http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/
Hamed, American Journal of Clinical Nutrition, July 2010:
http://www.ajcn.org/cgi/content/abstract/92/1/161
Mercken, E.M. American Journal of Clinical Nutrition, July 2010:
http://www.ajcn.org/cgi/content/full/92/1/1
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