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September 28, 2010
In Today's Issue
- 1 Quick Technique To Burn More Fat
- Known Obesity Gene Linked To Dementia Risk...
- Overweight? Shocking Proof that it may not be your fault
1 Quick Technique To Burn More Fat
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Known Obesity Gene Linked To Dementia Risk...
Dear Reader,
Some fascinating findings from a recent study on dementia. A variant of a gene related to obesity, FTO, appears to raise the risk of Alzheimer's disease and dementia according to a Swedish study presented at the July 2010 Alzheimer's Association International Conference on Alzheimer's Disease.
Earlier work has shown that the FTO gene is involved with things like body mass index (BMI), leptin (a hormone linked to appetite and metabolism) levels, the risk of diabetes, all vascular risk factors that are known to be linked to the risk of Alzheimer's.
Previous studies have shown that the FTO gene seems to be more involved with the type of calories you consume rather than how the body manages those calories. Experts are quick to point out that food choices and other factors can counter a genetic disposition.
It's important to understand that while you might have a gene that puts you at risk, this does not mean you're destined to get a disease. There may be other genes involved. What's more, living a healthy lifestyle and reducing stress may be more important than science has discovered.
The Swedish work included over 1,000 Swedish adults over 75 who were followed for nine years. Genetic testing was completed on all participants at the start of the study.
Those who carried an AA gene variant in the FTO gene had a 58% increased risk of developing Alzheimer's, a 48% increased risk for dementia compared to those who didn't have the genetic variant.
The researchers believe the risk could be 100% higher for someone who had the FTO-AA variant and a mutation known as APOE4. This is the highest risk variation of the gene APOE experts have linked to Alzheimer's disease.
Continues below...
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Known Obesity Gene Linked To Dementia Risk... Continued...
Dr. Caroline Graff of Sweden's Karolinska Institutet believes that the intriguing
aspect of her team's findings is that the increased risk of dementia was not
tied to other traits (obesity and diabetes, for example) experts had linked to
FTO in the past. The findings also fit with the understood connections between
heart and brain health according to Maria Carrillo, senior director of medical
and scientific relations at the Alzheimer's Association.
Alzheimer's disease is the most common cause for dementia in the Untied States
and most countries in the world. It's a slowly progressing disease of the brain
that brings memory impairment and disturbances in reasoning, planning, language
and perception. Experts know what happens, but they have yet to find any single
reason why these cells fail. This condition is not a normal part of the aging
process... it's not inevitable as you get older.
Further work will need to be done to confirm these results.
In the meantime, you need to understand that while there are some risk factors
you can't control - increasing age, family history and your genetic makeup, there
are others that you can do something about. Eating right, getting regular exercise
and managing your stress level are all important. Keeping your heart healthy,
not using tobacco and alcohol and avoiding head injury are other important ways
to keep yourself healthy in both body and mind.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=117982
July 2010 Alzheimer's Association International Conference on Alzheimer's Disease:
http://www.alz.org/icad/
MedicineNet info on Alzheimer's disease:
http://www.medicinenet.com/alzheimers_disease/article.htm
Alzheimer's Association:
http://www.alz.org/index.asp
MedicineNet info on dementia:
http://www.medicinenet.com/dementia/article.htm
MedicineNet info on diabetes:
http://www.medicinenet.com/diabetes_mellitus/article.htm
WebMD info on the FTO obesity gene:
http://www.webmd.com/diet/news/20081210/how-the-fto-obesity-gene-works
Dr. Caroline Graff of Sweden's Karolinska Institutet:
http://ki.se/ki/jsp/polopoly.jsp?d=34540&l=en
Maria Carrillo, senior director, Alzheimer's Association:
http://caring-for-alzheimers.com/maria-carrillo-ph-d-senior-director-medical-and-scientific-relations-alzheimers-association.php
Alzheimer's Association, July 12, 2010, news release:
http://www.alz.org/icad/2010_release_obesitygene_071210_730pm.asp
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