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January 19, 2011
In Today's Issue
- Weight Loss Expert Loses 70lbs of Ugly Fat...
- Belly Fat Increases Risk of Some Breast Cancers...
- WARNING: The truth about Moles, Warts and Skintags...
Weight Loss Expert Loses 70lbs of Ugly Fat...
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Belly Fat Increases Risk of Some Breast Cancers...
Dear Reader,
New research reveals that premenopausal women who carry extra fat around the middle, or have a larger waist to hip size, may have an increased risk of a specific type of breast cancer, estrogen receptor (ER) negative. Having body fat in this area was linked more strongly to the risk of this specific type of cancer than it was for the ER-positive variety or to breast cancer itself according to the work that appears in the Journal of the National Cancer Institute.
In 2010, an estimated 207,090 U.S. women will be told they have invasive breast cancer. Another 54,010 cases of non-invasive breast cancer will also be diagnosed. The good news is that rates of breast cancer have been decreasing by almost 2% a year, as have death rates from the disease.
Doctor's know that many breast tumors are sensitive to the hormone estrogen, and pathology reports typically identify which type of cancer a patient has.
Estrogen receptor negative breast cancer is diagnosed when the cancer lacks receptors for the female hormone estrogen, so this hormone doesn't stimulate cancer growth.
Estrogen receptor positive cancers are those where cell growth is influenced by estrogen, and are responsive to treatment with tamoxifen because this drug blocks the interaction between estrogen and the estrogen receptor.
The research team, lead by Holly R. Harris of Brigham and Women's Hospital and Harvard Medical School, acknowledged that body fat composition has a complicated relationship with the risk of cancer. Having a higher BMI for example, has been linked to a rise in the risk of postmenopausal breast cancer, but not premenopausal breast cancers.
In the latest bit of research, Harris and her team focused on data from over 116,000 women who were enrolled in the Nurses Health Study II who had waist and hip circumference recorded.
It seems that premenopausal women who carry extra fat around the organs in the abdominal region are more likely to develop hyperinsulinemia (a pre-diabetic condition). Experiments in the lab have shown that insulin receptors can promote the growth of breast cancer cells.
The fact that ER-negative breast cancer was more strongly linked to fat in the abdomen and the waist-hip ratio than ER-positive breast cancer makes experts think that the means by which body fat distribution somehow gets around the sex hormone pathways. The findings are the first to point out that an insulin related pathway related to belly fat may be involved in the development of breast cancer in premenopausal women.
Continues below...
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WARNING: The truth about Moles, Warts and Skintags...
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Belly Fat Increases Risk of Some Breast Cancers... Continued...
Many women notice an abundance of belly fat as they get older, especially after
menopause. As you've heard, putting the pounds in this area is particularly unhealthy
as compared to other parts of the body, increasing your risk of heart disease,
diabetes and even some cancers. It seems that the fat cells in the abdomen don't
just sit there adding extra bulk; they are active and produce hormones and other
substances that can impact your health.
If you're concerned about your risk of breast cancer, and know you're carrying
more belly fat than you should be, now's the time to make changes in your diet
and fitness routine. You may not see it all on the outside, but losing even a
few pounds can have many positive impacts on your body and your health.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=123576
News release from Brigham and Women's Hospital:
http://healthlibrary.brighamandwomens.org/RelatedItems/6,647547
Breast cancer info at breastcancer.org:
http://www.breastcancer.org/
National Cancer Institute info on estrogen receptors and cancer:
http://www.cancer.gov/cancertopics/understandingcancer
/estrogenreceptors/Slide18
National Cancer Institute breast cancer risk assessment tool:
http://www.cancer.gov/bcrisktool/
Mayo Clinic info on how to keep off belly fat:
http://www.mayoclinic.com/health/belly-fat/WO00128
Study abstract in Journal of the National Cancer Institute, December 16, 2010:
http://jnci.oxfordjournals.org/content/early/2010/12/15
/jnci.djq500.abstract?sid=5316c72e-5994-4503-8ccc-c1bd8034211b
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