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March 28, 2011
In Today's Issue
- 1 Quick Technique To Burn More Fat
- Obesity Boosts Risk Of Aggressive Breast Cancer...
- Celebrity Endorsed Weight Loss and Detox System
1 Quick Technique To Burn More Fat
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Obesity Boosts Risk Of Aggressive Breast Cancer...
Dear Reader,
More news on carrying too many pounds. Being obese is something doctors know ups the risk of estrogen-fueled breast cancer in women who have gone through menopause. There's new research that appears in the journal Cancer Epidemiology, Biomarkers & Prevention that suggests a link between obesity after menopause and an extra aggressive form of breast cancer that is particularly hard to treat.
There were an estimated 207,000 women diagnosed with breast cancer in the U.S. during 2010. Just 10-20% of all breast cancers are the triple negative form that's marked by a lack of estrogen, progesterone and HER2 protein expression. Though uncommon, this form of breast cancer is far more aggressive, so the outlook is not as rosy as we'd like, mostly due to the lack of targeted treatment for this form of the disease. Biologically, this subtype of breast cancer is very different from other forms.
Researchers looked at data on 155,723 women who were part of the Women's Health Initiative. This is a large study of women after menopause that started in 1993, and examined diseases like cancer, heart disease and osteoporosis. The subjects were aged 50 to 79 years old and supplied information on their exercise habits, height and weight so that BMI numbers could be calculated.
During the lengthy follow up, 2,610 women were diagnosed with estrogen receptor positive breast cancer (fueled by estrogen) and 307 developed the triple-negative form of the disease. The subjects were divided into four groups based on their BMI; the participants at the top of the scale had BMIs of 31 of higher. As the researchers looked at the risks of obesity, they controlled for factors like age, education, income, ethnicity and family history.
The work found that women who had the highest BMIs had a 35% increased risk of developing the aggressive from of cancer, triple-negative, compared to those who had the lowest BMIs according to study lead Amanda Phipps who is a postdoctoral fellow at the Fred Hutchinson Cancer Research Center. The study subjects had a 39% increased risk of other breast cancers as well.
The association was what researchers term "borderline" in terms of statistical significance, though Phipps believes this is explained by the smaller number of cases in the study.
The team also saw a modest link between being more physically active and lower risk of both (estrogen-receptor positive and triple-negative) kinds of breast cancer, suggesting that more exercise might help in terms of risk for these cancers. Being active will also help keep your weight under control, so it's a win-win.
Continues below...
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Obesity Boosts Risk Of Aggressive Breast Cancer... Continued...
Doctor's know that after menopause, most of the estrogen in a woman's body comes
from what fat she has, so the more fat, the more exposure the body gets to this
hormone. This is why experts have long accepted the link between obesity and
estrogen-positive breast cancers.
In fact, experts who reviewed the study, but didn't participate in it, such as
Dr. Joanne Mortimer from the City of Hope Comprehensive Cancer Center believe
that this latest research confirms that obesity and cancer risk aren't just an
estrogen problem. It's more than the estrogen feeding the cancer cells - the
fat cells might just create an environment cancer cells really like. Though we
all expect that fat is inert in the body, we are coming to find that fat cells
do a whole lot more than take up space.
Obesity is also known to raise markers of inflammation, levels of insulin and
insulin like growth factor - all perfectly capable of contributing to the growth
of a breast tumor.
More work is needed, but the message about keeping your weight under control,
all through you life, is a smart one, especially if you're worried about breast
cancer.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=126511
CDC info on obesity:
http://www.cdc.gov/obesity/index.html
The North American Menopause society on menopause:
http://www.menopause.org/
National Cancer Institute info on breast cancer:
http://www.cancer.gov/cancertopics/types/breast
Amanda Phipps, Ph.D., postdoctoral fellow, Fred Hutchinson Cancer Research Center:
http://www.washington.edu/alumni/partnerships/publichealth
/201008/students.html
Joanne Mortimer, M.D., director, women's cancers program, City of Hope Comprehensive Cancer Center, Duarte, CA:
http://www.cityofhope.org/directory/people/mortimer-joanne/Pages/default.aspx
Study abstract, March 2011, Cancer Epidemiology, Biomarkers & Prevention:
http://cebp.aacrjournals.org/content/early/2011/02/25/1055-9965.EPI-10-0974.abstract
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