[DHB] Concerned About Skin Cancer? Read This...

Published: Fri, 03/25/11

Subject: [DHB] Concerned About Skin Cancer? Read This...

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Daily Health Bulletin

March 25, 2011

In Today's Issue

  • WARNING: The truth about Moles, Warts and Skintags...
  • Easy, Noninvasive Test For Melanoma...
  • Weight Loss Expert Loses 70lbs of Ugly Fat...
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WARNING: The truth about Moles, Warts and Skintags...

There are so many "scare" stories that it's sometimes hard to know what to believe. Which is why this is so timely...

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Easy, Noninvasive Test For Melanoma...

Dear Reader,

When it comes to dangerous, deadly melanoma, we need every weapon we can get. Now a new test, a simple, noninvasive procedure that uses a special adhesive tape to painlessly gather cells from a skin lesion that looks suspicious can accurately identify melanoma in all stages, from early to advanced.

Today melanoma is often identified by visual exam followed by biopsy, an uncomfortable, somewhat painful procedure that collects cells that are then sent to a pathologist for examination.

A study in the British Journal of Dermatology reports on the new testing method used for a year at 18 sites across the United States, finding that it was able to identify melanomas 100% of the time with a 12% false positive rate.

That's better than anything in use today. Interestingly, there are studies that suggest 40 biopsies are done for every melanoma detected, and this is important to remember according to dermatologist Mitchell Kline from the New York Presbyterian-Weill Cornell Medical School. He believes this new test will give dermatologists a tool to assess patients before a biopsy, and with the low false positive rate, should reduce the number of more invasive procedures that need to be performed.

The experimental tape used in the study is able to harvest cells from the skin surface, and was developed by DermTech International, a La Jolla California based biotech company, also the source of funding for the research.

The test uses a patented technology called Epidermal Genetic Information Retrieval to collect RNA from a worrisome skin lesion. During the research, samples of RNA were sent to the lab for genetic analysis; earlier studies had already identified genes that are specific to melanomas. The latest analysis included 17 of these.

According to lead author William Wachsman, MD, PhD, the 17-gene biomarker is able to tell the difference between early and very invasive disease. Wachsman is both an associate professor of medicine and a staff physician and also serves on the scientific advisory board of the creators of the new test.

The DermTech researchers are trying to make this melanoma tape test more affordable, and there'll be lots more testing before they seek approval by the FDA. They hope (if all goes well) the test will be in the hands of doctors in about two years. Then it will be up to dermatologists to embrace the new procedure.

The new test might be especially appealing to those who don't want a biopsy scar on their face or another visible part of the body, or for times when a biopsy would cause undue pain.

Continues below...


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Easy, Noninvasive Test For Melanoma... Continued...

Experts tell us that melanoma incidence has increased dramatically over the last two decades. In the U.S., the increases are especially dramatic in specific populations - young women and older men. The National Cancer Institute has numbers that put the invasive melanoma rates up by just about 4% a year for women 15 to 34 years old since 1995. For men over 65, the rates have increased by almost 9% a year.

When it comes to melanoma, or any skin cancer, your best bet is to keep in mind the ABCD system
- Asymmetry (one half different from the other),
- Borders (irregular edges),
- Color (changes from one part to another) and
- Diameter (larger than a pencil eraser).

If you catch a melanoma early, it is very treatable. This form of cancer is far more dangerous (deadly) once the cancer cells have the chance to spread beyond the skin. Which is why new testing methods that are easy, noninvasive and accurate will always be a welcome addition.

To your good health,

Kirsten Whittaker
Daily Health Bulletin Editor




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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=125877

General info on melanoma:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001853/

WebMD info on biopsy:
http://www.webmd.com/cancer/what-is-a-biopsy

DermTech International:
http://www.dermtech.com/

More about Epidermal Genetic Information Retrieval, EGIR(TM):
http://www.dermtech.com/technology/egir-platform/index.php

Study abstract, Wachsman, W. British Journal of Dermatology:
http://www.dermtech.com/news-events/publications/pdf/Wachsman_et_al_BJD_Revised-Online1.pdf

William Wachsman, MD, PhD, associate professor, University of California, San Diego School of Medicine:
http://cancer.ucsd.edu/summaries/wwachsman.asp

Mitchell Kline, MD, clinical assistant professor of dermatology, New York Presbyterian-Weill Cornell Medical School:
http://www.nycdermatologyandcosmeticcenter.com/staff.html

Press release, 02/07/11, DermTech International:
http://www.dermtech.com/news-events/020711.php

National Cancer Institute, a snapshot of melanoma:
http://www.cancer.gov/aboutnci/servingpeople/snapshots/melanoma.pdf















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