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April 14, 2011
In Today's Issue
- Weight Loss Expert Loses 70lbs of Ugly Fat...
- Good Cholesterol Might Cut Colon Cancer Risks...
- Celebrity Endorsed Weight Loss and Detox System
Weight Loss Expert Loses 70lbs of Ugly Fat...
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Good Cholesterol Might Cut Colon Cancer Risks...
Dear Reader,
Important news on colon cancer. If you have high levels of "good" cholesterol, you might also have a reduced risk of colon cancer according to a new study appearing online in the journal Gut.
If future work confirms this finding, those with low levels of HDL (good) cholesterol should make changes to cut their risk of colon cancer advises lead researcher Dr. Bas Bueno-de-Mesquita, out of the National Institute for Public Health and the Environment in the Netherlands.
Doctors know that lowering bad (LDL) and increasing the good (HDL) cholesterol lowers your risk of heart disease. This work gives you yet another reason to watch those numbers - staying free of dangerous colon cancer.
In this work, the researchers compared 1,238 subjects with colorectal cancer to 1,238 healthy controls. Of the participants who had cancer - 779 had colon cancer, 459 had rectal cancer.
The team looked at blood samples and diet-lifestyle questionnaires filled out by the participants in the European Prospective Investigation into Cancer and Nutrition study. This is a long-term examination of the effect of diet on cancer that spans ten nations.
Bueno-de-Mesquita and his team found that subjects with the highest levels of HDL cholesterol, along with another blood fat known as apolipoprotein A (apoA), had the lowest chance of developing cancer of the colon. There was no impact on rectal cancer rates.
For each 16.6 milligrams per deciliter (mg/dl) increase in good cholesterol, colon cancer risk was reduced by 22%, while a 32% increase in apoA brought the risk of colon cancer down by 18%. For a subset of patients followed for over two years, only the HDL levels were associated with a reduced risk of colon cancer.
This particular association is independent of other markers in blood that are tied to the development of cancer. Things like inflammation, insulin resistance and oxygen free radicals. But is it the HDL cholesterol or some other biological factor that comes with good cholesterol that's responsible for the reduction in risk?
The short follow up period, only 3.6 years, is considered a limitation of the research, though the study is well designed according to experts at the American Cancer Society who had no part in the research, and is the largest ever of good cholesterol and risk of colon cancer.
Continues below...
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Good Cholesterol Might Cut Colon Cancer Risks... Continued...
Cancer of the colon starts in the large intestine (known medically as the colon)
or at the end of the colon, the rectum. The American Cancer Society points out
that colorectal cancer is a leading cause of cancer related deaths in the U.S.
Nearly all colon cancers start out as benign polyps that develop into cancer
over time. The good news is that finding the cancer early, at the polyp stage
when it's small and hasn't had chance to spread, is a key to a complete cure.
The team speculates that good cholesterol's anti-inflammatory properties might
be the reason for the finding, but understand that more work is needed. If other
studies bear out this finding, it may be that HDL levels become a useful tool
in assessing a patient's colon cancer risks.
If you're worried about your own risks of this form of cancer, the best recommendations
are to stop smoking, be more active on a regular basis (improves HDL levels too),
get your weight under control and limit your intake of both red/processed meats
and alcohol.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=140547
American Heart Association info on cholesterol:
http://www.heart.org/HEARTORG/Conditions/Cholesterol
/CholestrolATH_UCM_001089_SubHomePage.jsp
General info on apolipoprotein A (apoA):
http://en.wikipedia.org/wiki/Apolipoprotein_A1
More info on colon cancer:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/
Bas Bueno-de-Mesquita, M.D., Ph.D., gastroenterology & hepatology department, National Institute for Public Health and the Environment, Bilthoven, the Netherlands:
http://www.wcrf.org/cancer_research/regular_grant_
programme/funded_research/rivm/mesquita_b.php
March 7, 2011, Gut, online:
http://gut.bmj.com/content/early/2011/02/18/gut.
2010.225011.abstract?sid=f26f5efb-5cf2-4af4-b236-04ddff2c7280
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