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June 30, 2011
In Today's Issue
- 1 Quick Technique To Burn More Fat
- Risk Of Fractures Linked To These Common OTC Meds...
- Weight Loss Expert Loses 70lbs of Ugly Fat...
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Risk Of Fractures Linked To These Common OTC Meds...
Dear Reader,
A new analysis published in the Annals of Family Medicine suggests that long term users of medications known as proton pump inhibitors (PPIs) are at increased risk of fractures. The list of meds includes names you know, Nexium, Prevacid, Prilosec and Protonix, all common drugs given to help reduce the secretion of gastric acid that may also raise the risk of breaking a bone by just about 30%.
The current work by a team out of Seoul National University is an analysis of 11 studies published earlier where experts looked at the possible link between fracture risk and the proton pump inhibitors.
Overall they saw fracture increases of 29% for those taking PPIs - hip fractures were up by 31%, vertebral by 54%. There was not a significant association between fracture risk and the histamine H2-receptor antagonists, another of the acid suppressing medications out there under brand names like Axid, Pepcid, Tagamet and Zantac.
The researchers believe that the higher risk of fractures comes in part because PPIs get in the way of the body's ability to absorb calcium. This leads to weaker bones, more apt to break.
Most people have two fractures over a lifetime, and your risk depends in part on your age, your bones getting more brittle as the years pass.
You can get any of the PPIs by prescription or over the counter, and they are a well-tolerated recommendation for those who are diagnosed with gastroesophageal reflux disease (GERD for short), peptic ulcers, erosive esophagitis or Barrett's esophagus. They're the third largest selling class of drugs being sold today, with sales of $13.6 billion last year alone.
Your doctor will tell you that the benefits of these drugs, especially if you have one of these conditions, far outweigh any risk, a message echoed by James M. Gill, MD, MPH, lead author of the editorial published along with the research.
The trouble is, many people who take these medications don't truly need them.
Continues below...
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Risk Of Fractures Linked To These Common OTC Meds... Continued...
The study doesn't change anything in terms of guidelines a doctor would follow
in terms of prescribing. Rather, the experts suggest that doctors pay very close
attention to symptoms reported and be more discriminating when recommending these
medicines to their patients.
One thing more - fractures aren't the only risk of PPIs. These medications can
also raise the risk of gastrointestinal infections, and taking them for longer
than a year can bring on low serum magnesium levels that can cause muscle spasms,
irregular heartbeat and even convulsions. This warning came from the FDA just
recently, in March 2011.
The drug makers themselves point out that there are both risks and benefits to
any medication, including these. What's more, the PPI should only be used as
directed on the label. That's not more than 14 days for frequent heartburn. Many
people use these medications for far longer periods; if you find that's you,
talk with your doctor.
Going forward, researcher Gill suggests that doctors suggest the PPIs when the
need is clear and the potential complications serious, but for those with uncomplicated
GERD, a recommendation of taking the PPI as needed, might be better in the long
run.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.webmd.com/heartburn-gerd/news/20110509
/study-proton-pump-inhibitors-linked-to-fracture-risk?src=RSS_PUBLIC
MedicineNet info on proton pump inhibitors, PPIs:
http://www.medicinenet.com/proton-pump_inhibitors/article.htm
Web MD info on fractures:
http://www.webmd.com/a-to-z-guides/understanding-fractures-basic-information
U.S. National Library of Medicine info on GERD:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001311/
Peptic ulcer disease:
http://emedicine.medscape.com/article/181753-overview
About.com erosive esophagitis:
http://heartburn.about.com/od/complicationsofheartburn
/a/erodesophagitis.htm
U.S. National Library of Medicine info on Barrett's esophagus:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002128/
Study abstract, Eom, C. Annals of Family Medicine, May/June 2011; vol 9: pp 257-267:
http://www.annfammed.org/cgi/content/abstract/9/3/257
Editorial, Gill, J. Annals of Family Medicine, May/June 2011; vol 9: pp 200-202:
http://www.annfammed.org/cgi/content/full/9/3/200
FDA: "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of Proton Pump Inhibitor drugs (PPIs).":
http://www.fda.gov/Safety/MedWatch/SafetyInformation
/SafetyAlertsforHumanMedicalProducts/ucm245275.htm
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