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August 15, 2011
In Today's Issue
- Weight Loss Expert Loses 70lbs of Ugly Fat...
- Warning: Dangers of Common Painkillers Revealed...
- Announcing: Doctor Approved Store Cupboard Remedies that Really Work...
Weight Loss Expert Loses 70lbs of Ugly Fat...
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Warning: Dangers of Common Painkillers Revealed...
Dear Reader,
Painkillers regularly used to treat inflammation have been found to be associated with a higher risk of the dangerous heart rhythm condition known as atrial fibrillation according to a new study that appears online in BMJ.
Atrial fibrillation is the medical term for an irregular and often very rapid heart rate. Beyond causing poor blood flow throughout the body, this condition also brings with it an increased risk of heart failure, stroke and death. Today more than 2 million Americans, and 4 million in the European Union have this condition, many undergoing treatment with anticoagulant drugs.
The pain medications in question are ones we know. Non-steroidal anti-inflammatory drugs, NSAIDs, are used to bring down inflammation (from a disease like arthritis or an injury), ease pain and reduce fever. They do this by blocking enzymes and proteins naturally made by the body.
If you've been taking a NASID for more than ten days, you should talk with your doctor about your symptoms. Cox-2 inhibitors are a form of NASID that target the enzyme COX-2 that's involved with inflammation and pain.
Earlier research on painkilling medications and the heart has found NSAIDs and cox-2 inhibitors bring a higher risk of heart attack and stroke, but this is the first work to link the popular painkilling drugs to atrial fibrillation.
The Danish team from Aarhus University Hospital examined 32,602 patients who had a first diagnosis of atrial fibrillation during the years 1999 to 2008. Each patient was then compared to 10 age and gender matched healthy controls taken from Denmark's general population.
The researchers discovered that using these painkilling drugs was tied to a higher risk of atrial fibrillation - the link strongest among those who were new to using these medications. NSAIDs brought a 40% increase in risk, cox-2 inhibitors a whopping 70% higher risk.
This works out to be about 7 extra cases of dangerous atrial fibrillation for every 1,000 new users of cox-2 inhibitors - 4 extra cases for NSAIDS. For those just starting on a cox-2 inhibitor, the risk appeared highest in older adults and those who had conditions such as rheumatoid arthritis or chronic kidney disease.
Continues below...
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Warning: Dangers of Common Painkillers Revealed... Continued...
The researchers are hoping that the study causes doctors to consider atrial fibrillation
as a cardiovascular risk that must be considered when choosing to treat a patient
with these medications.
It's not like the drugs don't have their problems. In 2004 cox-2 inhibitor Vioxx
was abruptly pulled from the market because of an increased risk of heart attack
while taking it. In 2007 a warning to doctors against giving NSAIDS to heart
patients came from the American Heart Association. Then a study In July 2010
in the journal Circulation: Cardiovascular Quality and Outcomes showed that healthy
people who take NSAIDs on occasion might be at an increased risk of dying from
heart problems.
A 2011 review of existing research found that NSAIDS can also boost the risk
of stroke, heart attack, even death. These findings come from an analysis of
31 clinical trials involving NSAIDs that suggest a patient's heart health should
be considered before being given these medications. This work appeared in the
January 2011 issue of BMJ.
So what to do? If you or someone you love has heart issues, talk with your doctor
before taking these pain relievers, even on an occasional basis. While the risk
will need more study before being widely accepted, for those who already have
heart issues, being cautious with all medications is a smart move.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=146595
Mayo Clinic info on atrial fibrillation:
http://www.mayoclinic.com/health/atrial-fibrillation/DS00291
National Stroke Association for news and more on stroke:
http://www.stroke.org/site/PageNavigator/HOME
Mayo Clinic info on heart failure:
http://www.mayoclinic.com/health/heart-failure/DS00061
WebMD info on non-steroidal anti inflammatory, NSAIDs:
http://www.webmd.com/pain-management/nonsteroidal-anti-inflammatory-drugs-nsaids
MedicineNet info on cox-2 inhibitors:
http://www.medicinenet.com/cox-2_inhibitors/article.htm
BMJ, news release, July 4, 2011:
http://www.bmj.com/content/343/bmj.d2495.extract
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