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April 3, 2012
In Today's Issue
- Weight Loss Expert Loses 70lbs of Ugly Fat...
- Could Sleep Disturbances Be Associated With Alzheimer's Disease..?
- Fact: Poor Sleep Increases The Risk of Death/ Disease
Weight Loss Expert Loses 70lbs of Ugly Fat...
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Could Sleep Disturbances Be Associated With Alzheimer's Disease..?
Dear Reader,
Try to sleep after reading this... you're more likely to develop Alzheimer's disease if your sleep is poor... the idea really helps you drift off, doesn't it? New research, while preliminary, has found that waking all through the night, more than five times in an hour, may be a signal of preclinical Alzheimer's disease. Preclinical Alzheimer's is the term medical personnel use for those who have normal mental skills but also show the brain changes that are linked to this dreadful disease.
The research on sleep and Alzheimer's involved 100 subjects, both men and women who were aged between 45 to 80 years. All were dementia free at the start of the study, though half had a family history of Alzheimer's disease.
For two weeks the subjects wore a device that was able to measure sleep, while also filling out sleep diaries and questionnaires. The subjects slept for about six and a half hours, though they stayed in bed for another hour and a half, for a total of eight hours.
The research team analyzed subjects' spinal fluid, looked at brain scans for evidence of amyloid plaques - the deposits that are in the brains of those with Alzheimer's. Today experts think such deposits can be forming from 10 to 15 years before symptoms appear. About a quarter of the subjects had evidence of preclinical Alzheimer's, and those who woke most often (over 5 times an hour) were more likely than non-waking subjects to show abnormal biomarkers.
Study lead Yo- El Ju, MD, assistant professor of neurology at St. Louis' Washington University School of Medicine is due to present her findings on Alzheimer's and sleep in April as part of the annual meeting of the American Academy of Neurology. Keep in mind that studies presented at conferences are considered preliminary. The findings have yet to undergo the peer review process, where outside experts look at the data before it appears in a medial text.
The researchers also cannot put a number on the increase in risk for those who woke more often. Subjects who spent under 85% of their time in bed sleeping were more likely to have preclinical Alzheimer's. Waking five times an hour sounds like no sleep at all, and Ju admits that the measuring device might slightly over estimate the number of times subjects woke. Still most of us do wake up, briefly, quite a bit during a normal night of sleep.
Continues below...
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Fact: Poor Sleep Increases The Risk of Death/ Disease
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Could Sleep Disturbances Be Associated With Alzheimer's Disease..? Continued...
Are changes in the brain driving sleep disturbances, or is it the other way around?
Trouble sleeping could well be a reflection of changes happening in the brain.
We do know that getting a good night's sleep is very important for the brain.
More examination of the relationship between sleep and Alzheimer's is needed.
Ju is enrolling and evaluating another 100 subjects for further study, and expects
to have these results by the time of the meeting presentation.
Interestingly there are animal studies that find sleep changes do drive the accumulation
of amyloid. It wouldn't be surprising for this to be the case in humans as well.
The take home message? A good night's sleep is beneficial to your body, and we
should all try to make getting the right amount of restful, restorative sleep
a priority. Just as we do eating right and exercising. Sleep is equally important.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://www.medicinenet.com/script/main/art.asp?articlekey=154847
Alz.org info on Alzheimer's:
http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp
MedicineNet on Alzheimer's disease:
http://www.medicinenet.com/alzheimers_disease_causes_stages
_and_symptoms/article.htm
Helpguide.org info on dementia:
http://helpguide.org/elder/alzheimers_dementias_types.htm
Yo- El Ju, MD, assistant professor of neurology at St. Louis' Washington University School of Medicine:
http://sleep.wustl.edu/faculty-staff/
American Academy of Neurology annual Meeting, April 2012:
http://www.aan.com/go/am12
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