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April 18, 2013
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In Today's Issue
- Fact: Poor Sleep Increases The Risk of Death/ Disease
- How Peptide Is Responsible For Happiness?
- The Healthy Back Institute's Back Pain Relief Journal
Fact: Poor Sleep Increases The Risk of Death/ Disease
Ever lain awake at night and counted the hours till dawn? Isn't frustrating to be in bed and be unable to sleep? With around 18 million prescriptions written every year for expensive sleeping pills... ...it's clear that there's a national epidemic. So, what do doctors do when they can't sleep? Here's the answer. Learn how a retired M.D. Laney Chouest from New Orleans broke his 5-year addiction to Ambien, and now sleeps peacefully without medication. Also, discover how a Licensed Psychologist, Sharon Stein McNamara, Ed.D.fromMinnesota broke her insomnia cycle. Click through today to discover the 7 mistakes that are killing your sleep, and how overcome them...*Disclosure: compensated affiliate*
How Peptide Is Responsible For Happiness?
Dear Reader,
In the search for happiness, there are many things that are thought to bring it. Money. Family. Success. Loving relationships. Now, for the first time in human subjects, researchers from UCLA have measured the release of a specific peptide that went up when subjects were happy, decreased when they were sad. The work appears in the online edition of the journal Nature Communications.
For the current research, the team got data on the peptides they were studying directly from the brains of eight patients who were undergoing treatment at Ronald Regan UCLA Medical Center for intractable epilepsy. Other doctors had outfitted the participants with intracranial depth electrodes, and participants gave permission for researchers to use these same electrodes to do their own work. The subjects were recorded while they did everyday things and notes were made, samples collected every 15 minutes. Subjects also rated mood and attitude on a questionnaire that was administered every hour while they were awake.
One of the peptides studied, hypocretin, when boosted could also improve both mood and alertness. Could this provide a future treatment of psychiatric disorders such as depression? Researchers are unsure today, but the outlook is promising.
The study also measured the release of a different peptide, melanin concentrating hormone, or MCH, and found that the release was minimal while awake, but greatly increased when you sleep. This suggests a key role for this substance in helping people go to sleep.
The team noted that while hypocretin levels were not linked to general arousal they were maximized during positive emotions, anger, social involvement and waking up. MCH levels were maximized during the onset of sleep and minimized during social interactions. This suggests abnormalities in the activation of certain systems may contribute to an array of psychological disorders.
These findings may explain the sleepiness of narcolepsy and the depression that comes with this terribly disruptive disorder according to senior author Jerome Siegel, a professor of psychiatry and director of the Center for Sleep Research at UCLA's Semel Institute for Neuroscience and Human Behavior. A deficiency of hypocretin may also be behind depression from other causes.
Back in 2000 Siegel's team made news with findings that showed those who had narcolepsy also had 95% fewer hypocretin nerve cells in their brains than those without the illness. This was the first work to uncover a possible biological cause of this strange disorder that involves uncontrolled periods of deep sleep. As you might imagine depression is strongly linked to narcolepsy, and so Siegel's lab started to look at hypocretin and a possible link to depression.
Continues below...
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How Peptide Is Responsible For Happiness? Continued...
Narcolepsy is a neurological condition, often starting between the ages of 15 and 25, that affects the individual's control of wakefulness and sleep. Those who have the condition experience excessive sleepiness during the daytime, and they have intermittent, uncontrollable episodes where they fall asleep during the day. The attacks of sleep can happen at any time, and while doing anything. Often the condition goes undiagnosed.
Experts also tell us that depression, a medical illness not a sign of weakness or character flaws, is the leading cause of psychiatric disorders in the United States. More than 6% of the general population is affected, with lifetime prevalence up over 15%. There has also been recent research that antidepressants are any more effective than a placebo medication.
While science still doesn't know very much about the neurochemical changes that are behind our emotions and social behavior, we're getting closer. Today hypocretin antagonists are being developed by a few drug makers for use as sleeping aids and more research in the area is sure to follow.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://newsroom.ucla.edu/portal/ucla/peptide-a-key-to-happiness-244002.aspx
WebMD info on narcolepsy:
http://www.webmd.com/sleep-disorders/guide/narcolepsy
WebMD info on depression:
http://www.webmd.com/depression/default.htm
UCLA news release on study, March 6, 2013:
http://newsroom.ucla.edu/portal/ucla/peptide-a-key-to-happiness-244002.aspx?link_page_rss=244002
UCLA news release, August 29, 2000 on earlier Siegel work on narcolepsy: http://newsroom.ucla.edu/portal/ucla/UCLA-VA-Study-Solves-120-Year-Mystery-1732.aspx
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