[DHB] Are You At Risk Of A Heart Attack?...

Published: Tue, 05/21/13

Subject: [DHB] Are You At Risk Of A Heart Attack?...

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In Today's Issue

  • Are Your Genetics Keeping You Fat? (1 tip to change fast)
  • Your Stomach Can Predict A Heart Attack Risk.
  • FREE Top Rated simple weight loss tips...
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Your Stomach Can Predict A Heart Attack Risk.

Dear Reader,

If you're concerned about your own, or a loved ones, risk of heart disease or stroke, here's news you'll want to hear. Researchers from the Cleveland Clinic have found that a new blood test that measures something in the blood that's naturally generated by the organisms that live in your stomach, can tell if you're likely to have heart trouble later on. The substance produced by the stomach is known as trimethylamine-N-oxide (TMAO for short), and if you've never heard of it before, you'll start very soon.

The current study involved collecting data on TMAO levels from over 4,000 patients and following them for an average of 3 years. The team saw that as TMAO levels went up, so did the risk for heart attack, stroke or another heart disease. Those who had the most TMAO in the blood had 2.5 times the risk for such an outcome compared to those who had the lowest levels.

What's more, testing for TMAO predicted risk to the heart better than other blood tests in use today as well as factors like high blood pressure, elevated cholesterol numbers and even smoking according to lead researcher Dr. Stanley Hazen from the Clinic's Lerner Research Institute. It's incredible news, and gives medicine a new risk factor to target with testing, as well as the opportunity to prevent heart related issues in patients before they happen.

The researchers saw that dietary choline (in egg yolks) is changed into TMAO, as is carnitine that's found in red meat. TMAO appears to change how the body metabolizes cholesterol, not removing it, but rather changing how the cholesterol is being managed. TMAO helps cholesterol attach to blood vessels and makes it hard for both the liver and intestines to get rid of it.

Since TMAO appears to be related to diet (those who eat the most red meat have the highest levels), those at risk could tailor their diets to cut the risk of devastating heart issues later on. By eating a heart healthy diet low in fats, dairy and sugar TMAO can be brought into line. Interesting that the study found vegetarians had the lowest levels of this compound. Making a change in diet to impact this substance seems promising.


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Your Stomach Can Predict A Heart Attack Risk. Continued...


Over the years there's been a good deal of research interest in the role of the intestinal organisms might play in both metabolic and cardiac disease. Other recent work has suggested that TMAO might have a part in the initiation and progression of dangerous atherosclerosis - the buildup of harmful plaque on artery walls. More work will be needed before we fully understand this substance and what it does in the body.

Whether TMAO could be a marker of cardiovascular disease risk, or something we can target to reduce risk is still unclear. An editorial that accompanies the study in the April 25, 2013 New England Journal of Medicine points out that these finding suggest many possible novel approaches for preventing heart disease. Probiotics, in addition to limiting certain choline rich foods might also be helpful.

However the research ends up, by eating right and being active on a regular basis, you'll be doing all you can to keep your body, and your heart, healthy and going strong for years to come.

To your good health,

Kirsten Whittaker
Daily Health Bulletin Editor




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Sources:
http://www.webmd.com/heart-disease/news/20130424/gut-reaction-may-predict-cardiovascular-risk?src=RSS_PUBLIC

WebMD Heart Disease Health Center:
http://www.webmd.com/heart-disease/default.htm

American Heart Association info on heart healthy diet:
http://www.heart.org/HEARTORG/GettingHealthy/NutritionCenter/
Nutrition-Center_UCM_001188_SubHomePage.jsp

Stanley Hazen, M.D., Ph.D., Lerner Research Institute, Cleveland Clinic, Ohio:
http://www.lerner.ccf.org/cmm/hazen/

Study abstract, April 25, 2013, New England Journal of Medicine:
http://www.nejm.org/doi/full/10.1056/NEJMoa1109400


















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