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June 17, 2013
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In Today's Issue
- 3 critical reasons you have cellulite...
- Cancer Prevention : All The Latest Research
- Announcing: Doctor Approved Store Cupboard Remedies that Really Work...
3 critical reasons you have cellulite...
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Cancer Prevention : All The Latest Research
Dear Reader,
Cancer is a viciously clever disease; a disease that draws lots of research interest as medicine struggles to find ways to conquer it. At a briefing for journalists held in advance of the 49th annual The American Society of Clinical Oncology conference, highlights of some of the most promising studies have been released early.
First up is work on exercise and cancer that finds workouts might just be the newest weapon in the war against the disease. Recent research has found that being in good shape may be an effective way to prevent cancer, as well as improving survival rates for patients after they get that life-altering diagnosis.
The study on exercise was conducted out of the University of Vermont and involved more than 17,000 male subjects who were followed for almost 20 years. The men who exercised the most were 68% less likely to have lung cancer, 38% less likely to have colorectal cancers than the men who were the least active. For those who were diagnosed with either of these two cancers, exercising helped bring down the death risk by 14% for each increase in fitness level.
Next, there is research on immunotherapy, medications that train your own immune system to both recognize and kill cancer. It's a promising idea that one of these studies previewed before the meeting found that a new antibody, MPDL3280A, was able to shrink tumors in 21% of the patients taking part in the study, all victims of melanoma, lung or kidney cancer. The drug was well tolerated at all doses, and adverse reactions were infrequent.
There are also results from a first phase clinical trial of MPDL3280A that sought to establish safety and dosing guidelines. Now that this drug has been found to be safe and well tolerated, the next step is a much larger trail with lots more people. The early results on MPDL3280A are promising, so watch for more news.
The second study on immunotherapy treatment found that the combination of two drugs, FDA approved Yervoy and yet to be FDA approved Nivolumab may help shrink the size of melanoma tumors. More than half the participants in the study saw their tumors shrink by more than 50% in the first 12 weeks of treatment. That's just incredible. Until Yervoy got FDA approval two years ago, those who had melanoma had no treatment options.
After years of little success in immunotherapy, there are now two studies that show some promise according to the president of the American Society of Clinical Oncology Dr. Sandra Swain. These two therapies are bringing very rapid, profound and lasting shrinkage of tumors, and this hasn't been seen before with other immunotherapies that have been studied. Very exciting.
Continues below...
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Cancer Prevention : All The Latest Research Continued...
The final three studies discussed at the briefing focused on existing cancer
therapies in an effort to evaluate which were proving the most effective. A study
from Washington University in St. Louis found that a 25% stronger radiation dose
for a type of lung cancer known as non small cell lung cancer was in fact more
dangerous to the patient, and less effective in treating the cancer itself. Doctors
expected using a higher dose would mean better outcomes, so this was a surprise.
Another study evaluated the effectiveness of post surgery chemotherapy and radiation for those who had seminoma, a common form of testicular cancer, versus follow up monitoring. This work involved 1,800 patients who had stage 1 seminoma living in Denmark where the protocol calls for regular visits, CT scans, X-rays and blood testing, not chemo or radiation as used in may U.S. treatment centers. What's interesting is that more than 80% of the patients didn't relapse after surgery, which eliminated the need for chemo or radiation. In those who did relapse, follow up treatment brought a 99.5% survival rate. Watching is safe.
The final study examined if patients who had a certain form of non-Hodgkin lymphoma should undergo regular CT scans to watch for relapse. The research saw that most relapses weren't detected by the scans, but by patient complains of symptoms, a routine physical or blood testing. So doctors can spare patients the cost and extra radiation of follow up CT scans.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
http://edition.cnn.com/2013/05/16/health/cancer-research/index.html?utm_source=feedburner&utm_medium=
feed&utm_campaign=
The American Society of Clinical Oncology: http://www.asco.org
The American Society of Clinical Oncology briefing on research: http://www.asco.org/press-center/asco-releases-studies-49th-annual-meeting
Find abstracts from 2013 annual meeting: http://chicago2013.asco.org
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